Ruthenium-catalyzed direct methylation of primary and secondary aromatic amines using carbon dioxide and molecular hydrogen.
نویسندگان
چکیده
منابع مشابه
Catalytic methylation of aromatic amines with formic acid as the unique carbon and hydrogen source.
A novel methodology is presented for the direct methylation of amines, using formic acid as a unique source of carbon and hydrogen. Based on ruthenium(II) catalysts, the formation of the N-CH3 group proceeds via an efficient formylation/transfer hydrogenation pathway.
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The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(i) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
متن کاملUnexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines.
Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2(mesitylene)]2 (1-2 mol%) as the catalyst at 100 °C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 36 شماره
صفحات -
تاریخ انتشار 2013